{"id":10755,"date":"2025-01-23T06:52:37","date_gmt":"2025-01-23T06:52:37","guid":{"rendered":"https:\/\/sindromecharge.es\/index.php\/2025\/01\/23\/investigadores-logran-dar-un-paso-clave-hacia-comprension-las-bases-biologicas-geneticas-trastorno-bipolar\/"},"modified":"2025-01-23T06:52:37","modified_gmt":"2025-01-23T06:52:37","slug":"investigadores-logran-dar-un-paso-clave-hacia-comprension-las-bases-biologicas-geneticas-trastorno-bipolar","status":"publish","type":"post","link":"https:\/\/sindromecharge.es\/index.php\/2025\/01\/23\/investigadores-logran-dar-un-paso-clave-hacia-comprension-las-bases-biologicas-geneticas-trastorno-bipolar\/","title":{"rendered":"Una investigaci\u00f3n da un \u00abpaso clave\u00bb para comprender las bases biol\u00f3gicas y gen\u00e9ticas del trastorno bipolar"},"content":{"rendered":"<p>Leemos en Discapacidad la siguiente noticia que os reproducimos de forma \u00edntegra: <\/p>\n<div>\n<p>La red internacional de investigadores <b>Consorcio de Psiquiatr\u00eda Gen\u00f3mica<\/b> ha logrado completar el <b>\u00abmayor estudio gen\u00e9tico\u00bb sobre el trastorno bipolar<\/b>, lo que ha permitido dar un \u00abpaso clave\u00bb hacia la comprensi\u00f3n de esta enfermedad,<b> que afecta a cerca de 50 millones de personas y que es una de las principales causas de <a href=\"https:\/\/www.20minutos.es\/minuteca\/discapacidad\/\" title=\"Discapacidad\" target=\"_blank\">discapacidad<\/a><\/b> a nivel mundial.<\/p>\n<p>\u00abEl an\u00e1lisis nos ha permitido identificar<b> 298 regiones gen\u00e9ticas asociadas con el trastorno<\/b>, cuadruplicando los descubrimientos de estudios anteriores, y se han encontrado<b> asociaciones gen\u00e9ticas espec\u00edficas <\/b>en poblaciones asi\u00e1ticas orientales, lo que abre nuevas perspectivas para comprender c\u00f3mo var\u00eda el trastorno bipolar entre diferentes grupos \u00e9tnicos\u00bb, ha indicado el doctor Claudio Toma, del <b>Centro de Biolog\u00eda Molecular Severo Ochoa<\/b> (CBM- CSIC-UAM), que ha participado en la investigaci\u00f3n.<\/p>\n<p>Este estudio,<b> publicado en la revista &#8216;Nature&#8217;<\/b>, ha analizado a m\u00e1s de 158.000 individuos con trastorno bipolar y 2,8 millones de controles, incluyendo poblaciones europeas, asi\u00e1ticas, afroamericanas y latinas.<\/p>\n<p>Aunque este tipo de trastornos tienen una alta heredabilidad (entre el 60 y el 80 por ciento),<b> gran parte de los factores gen\u00e9ticos que lo originan son desconocidos<\/b>, si bien los cient\u00edficos han logrado identificar diferencias gen\u00e9ticas entre los subtipos de esta condici\u00f3n.<\/p>\n<p>El <b>tipo I<\/b>, caracterizado por episodios <b>man\u00edacos graves<\/b>, muestra mayor relaci\u00f3n gen\u00e9tica con la <a href=\"https:\/\/www.20minutos.es\/minuteca\/esquizofrenia\/\" title=\"Esquizofrenia\" target=\"_blank\">esquizofrenia<\/a>, mientras que el<b> tipo II<\/b>, asociado a <b>episodios depresivos frecuentes<\/b> y menor man\u00eda, comparte mayor similitud gen\u00e9tica con la depresi\u00f3n mayor y el trastorno por d\u00e9ficit de atenci\u00f3n con hiperactividad (<b>TDAH<\/b>).<\/p>\n<p>Durante la investigaci\u00f3n se han logrado identificar 298 ubicaciones f\u00edsicas \u00absignificativas\u00bb en el genoma tras el metaan\u00e1lisis de ascendencia m\u00faltiple, un aumento de cuatro veces con respecto a los hallazgos anteriores, e incluso se ha identificado una<b> asociaci\u00f3n espec\u00edfica de ascendencia en la cohorte de Asia oriental<\/b>.<\/p>\n<p>Adem\u00e1s, han logrado un \u00abavance notable\u00bb tras<b> identificar 36 genes directamente implicados en la biolog\u00eda del trastorno bipolar<\/b>, de los que algunos presentan variantes \u00abraras\u00bb que alteran gravemente las prote\u00ednas de los individuos afectados, y que convergen en el desarrollo de la enfermedad.<\/p>\n<p>Asimismo, se han vinculado las se\u00f1ales gen\u00e9ticas de variantes comunes y raras con tipos espec\u00edficos de c\u00e9lulas cerebrales, como las interneuronas GABA\u00e9rgicas y las neuronas espinosas medianas, y con c\u00e9lulas fuera del <b>sistema nervioso central<\/b>, como las del intestino y el p\u00e1ncreas.<\/p>\n<p>\u00abEstos hallazgos ampl\u00edan la <b>perspectiva biol\u00f3gica del trastorno bipolar<\/b>, sugiriendo que otros \u00f3rganos aparte del cerebro podr\u00edan desempe\u00f1ar un papel relevante en su desarrollo (&#8230;) Podr\u00eda abrir la puerta a futuros tratamientos personalizados y mejores estrategias de diagn\u00f3stico\u00bb, han a\u00f1adido los cient\u00edficos.<\/p>\n<\/div>\n<p>Fuente: Discapacidad https:\/\/www.20minutos.es\/noticia\/5675262\/0\/investigadores-logran-dar-un-paso-clave-hacia-comprension-las-bases-biologicas-geneticas-trastorno-bipolar\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El trastorno bipolar afecta a 50 millones de personas y es una de las principales causas de discapacidad.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-10755","post","type-post","status-publish","format-standard","hentry","category-noticias"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Una investigaci\u00f3n da un &quot;paso clave&quot; para comprender las bases biol\u00f3gicas y gen\u00e9ticas del trastorno bipolar - Asociaci\u00f3n Espa\u00f1ola S\u00edndrome de Charge<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sindromecharge.es\/index.php\/2025\/01\/23\/investigadores-logran-dar-un-paso-clave-hacia-comprension-las-bases-biologicas-geneticas-trastorno-bipolar\/\" \/>\n<meta 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